Prognostic tools for hypertrophic scar formation based on fundamental differences in systemic immunity
نویسندگان
چکیده
منابع مشابه
Update on hypertrophic scar treatment
Scar formation is a consequence of the wound healing process that occurs when body tissues are damaged by a physical injury. Hypertrophic scars and keloids are pathological scars resulting from abnormal responses to trauma and can be itchy and painful, causing serious functional and cosmetic disability. The current review will focus on the definition of hypertrophic scars, distinguishing them f...
متن کاملThe molecular basis of keloid and hypertrophic scar formation.
Excess scar formation secondary to traumatic or surgical injuries can have devastating consequences, ranging from body disfigurement to organ dysfunction. Hypertrophic scars and keloids are skin fibrotic conditions that can be caused by minor insults to skin, such as acne or ear piercing, or by severe injuries such as burns. Differences between keloids, hypertrophic scars and normal scars inclu...
متن کاملMechanical load initiates hypertrophic scar formation through decreased cellular apoptosis.
Hypertrophic scars occur following cutaneous wounding and result in severe functional and esthetic defects. The pathophysiology of this process remains unknown. Here, we demonstrate for the first time that mechanical stress applied to a healing wound is sufficient to produce hypertrophic scars in mice. The resulting scars are histopathologically identical to human hypertrophic scars and persist...
متن کاملPotential cellular and molecular causes of hypertrophic scar formation.
A scar is an expected result of wound healing. However, in some individuals, and particularly in burn victims, the wound healing processes may lead to a fibrotic hypertrophic scar, which is raised, red, inflexible and responsible for serious functional and cosmetic problems. It seems that a wide array of subsequent processes are involved in hypertrophic scar formation, like an affected haemosta...
متن کاملPrevention and curative management of hypertrophic scar formation.
Although hypertrophic scarring commonly occurs following burns, many aspects such as incidence of and optimal treatment for scar hypertrophy remain unclear. This review will focus on hypertrophic scar formation after burn in particular, exploring multiple treatment options and describing their properties as well as effectiveness. To evaluate treatment efficacy and scar development, clinical sca...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2020
ISSN: 0906-6705,1600-0625
DOI: 10.1111/exd.14139